p16/INK4A impairs homologous recombination-mediated DNA repair in human papillomavirus (HPV) positive-head and neck tumors
نویسندگان
چکیده
Rüveyda Dok, Peter Kalev 3, , Evert Jan Van Limbergen , Layka Abbasi Asbagh, IriaVázquez 2, , Esther Hauben , Anna Sablina , Sandra Nuyts 5 KU Leuven, University of Leuven, Department of Oncology, Laboratory of Experimental Radiotherapy, 3000 Leuven, Belgium KU Leuven, University of Leuven, Department of Human Genetics, Laboratory for Mechanisms of Cell Transformation, 3000 Leuven, Belgium 3 VIB Center for the Biology of Disease, 3000 Leuven, Belgium Current address: Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, 02215 Massachusetts, USA Department of Radiation Oncology, UZ Leuven, 3000 Leuven, Belgium KU Leuven, University of Leuven, Department of Oncology, Molecular Digestive Oncology, 3000 Leuven, Belgium Department of Pathology, UZ Leuven, 3000 Leuven, Belgium KU Leuven, University of Leuven, Department of Imaging & Pathology, Translational Cell & Tissue Research , 3000 Leuven, Belgium Running title: p16 impairs HR-mediated DNA repair in head and neck cancers
منابع مشابه
p16INK4a impairs homologous recombination-mediated DNA repair in human papillomavirus-positive head and neck tumors.
The p16INK4a protein is a principal cyclin-dependent kinase inhibitor that decelerates the cell cycle. Abnormally high levels of p16INK4a are commonly observed in human papillomavirus (HPV)-positive head and neck squamous cell carcinomas (HNSCC). We and others found that p16INK4a overexpression is associated with improved therapy response and survival of patients with HNSCC treated with radioth...
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Head and neck squamous cell carcinoma (HNSCC) patients with human papillomavirus (HPV) infection have better prognosis than those without HPV infection. Although p16(INK4a) expression is used as a surrogate marker for HPV infection, there is controversy as to whether p16(INK4a) reliably indicates HPV infection. Here, to evaluate the accuracy of p16(INK4a) expression for determining HPV infectio...
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BACKGROUND Chemical carcinogens induce squamous cell carcinoma (SCC) of the head and neck by targeting the p53 and the retinoblastoma (pRb) pathways. Human papillomavirus (HPV) might have an etiologic role in these cancers at particular sites. Few studies have compared cell cycle protein expression in HPV-positive and HPV-negative tumors in this region. METHODS Fifty tonsil SCCs were analyzed...
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UNLABELLED Squamous cell carcinoma of the head and neck (SCCHN) is the sixth most common type of cancer worldwide; 600,000 new cases are diagnosed every year. Infected with high-risk human papilloma virus (HPV) types are particularly linked to oropharyngeal cancer. Among over 100 different HPV types, HPV-16 and HPV-18 are detected in the majority of HPV-positive SCCHNs. The p16 gene is often mu...
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Patients with human papillomavirus DNA positive (HPV(DNA+)) oropharyngeal squamous cell carcinoma (OSCC) have better clinical outcome than those with HPV DNA negative (HPV(DNA-)) OSCC upon intensive oncological treatment. All HPV(DNA+) OSCC patients may not require intensive treatment, however, but before potentially deintensifying treatment, additional predictive markers are needed. Here, we e...
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